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female nxg mice  (Janvier Labs)

 
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    Janvier Labs female nxg mice
    Female Nxg Mice, supplied by Janvier Labs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/nxg+female+mice/mice+nxg/pm42157284-137-2-6
    Average 86 stars, based on 1 article reviews
    female nxg mice - by Bioz Stars, 2026-09
    86/100 stars

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    Injection:

    Article Title: An IgE antibody targeting HER2 identified by clonal selection restricts breast cancer growth via immune-stimulating activities.
    Article Snippet: .. cient mice reconstituted with human PBMC For the dose and scheduling study of human IgE 26, 6–8 weeksold NOD-Prkdcscid‐IL2rgTm1/Rj (NXG, Janvier) female mice were injected s.c. into the right flank with 1 × 107 JIMT-1 breast cancer cells 1:1 in Matrigel® (day 0). ..

    Article Title: MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer.
    Article Snippet: .. For the human breast cancer patient-derived xenograft model, 25,000 MDA-MB-468 cells overexpressing Akaluc or MYC-P2A-Akaluc were injected into the fourth mammary glands of 6-wk-old immunodeficient NXG (Janvier labs) female mice, as previously described (Valdez et al., 2011; Hutten et al., 2023). ..

    Article Title: MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer
    Article Snippet: .. For the human breast cancer patient-derived xenograft model, 25,000 MDA-MB-468 cells overexpressing Akaluc or MYC-P2A-Akaluc were injected into the fourth mammary glands of 6-wk-old immunodeficient NXG (Janvier labs) female mice, as previously described ( ; ). ..

    Sterility:

    Article Title: Antimetastatic effects of MRTX1133 KRAS G12D specific inhibitor in a liver metastatic model of pancreatic ductal adenocarcinoma
    Article Snippet: .. NXG female mice were obtained from Janvier Labs (Le Genest-Saint-Isle, France) and were kept in a sterile environment in Makrolon® cages at 22–24 °C (40–50% humidity), with a 12-h light–dark cycle. ..

    Article Title: Antimetastatic effects of MRTX1133 KRAS G12D specific inhibitor in a liver metastatic model of pancreatic ductal adenocarcinoma.
    Article Snippet: .. NXG female mice were obtained from Janvier Labs (Le Genest-Saint-Isle, France) and were kept in a sterile environment in Makrolon® cages at 22–24 °C (40–50% humidity), with a 12-hour light-dark cycle. ..

    Multiple Displacement Amplification:

    Article Title: MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer.
    Article Snippet: .. For the human breast cancer patient-derived xenograft model, 25,000 MDA-MB-468 cells overexpressing Akaluc or MYC-P2A-Akaluc were injected into the fourth mammary glands of 6-wk-old immunodeficient NXG (Janvier labs) female mice, as previously described (Valdez et al., 2011; Hutten et al., 2023). ..

    Article Title: MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer
    Article Snippet: .. For the human breast cancer patient-derived xenograft model, 25,000 MDA-MB-468 cells overexpressing Akaluc or MYC-P2A-Akaluc were injected into the fourth mammary glands of 6-wk-old immunodeficient NXG (Janvier labs) female mice, as previously described ( ; ). ..



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    ( a ) BLI luminescence quantification of luciferase signal day 21 after intravenous inoculation of Luciferase-transduced JEKO-1 cell in immunodeficient NXG mice (n=5 per group) and injection of 0.5M CAR T cells expanded with IL2/7/15 or Ag-scaffolds on day 7. Cell numbers were adjusted for the actual number of CAR- expressing T cells. (b) Quantification of cancer cell growth from luminescence signal (e-/sec) over time following injection of 0.25M or 0.5M CAR T cells 7 days after jeko-1 injection (n=5 mice per group). Mice were terminated when reaching a predefined humane endpoint. (c-e) On day 30, spleens and bone marrow (BM) from the IL2/7/15 and Ag-scaffold-expanded 0.5M CAR T cell groups were analysed by flow cytometry, and CAR T cell percentages ( c ) representative flow plots showing CD3 + CAR T cell population (top) and CD3 + CD4 + & CD3 + CD8 + T cells(bottom) and numbers of CAR T cells ( d ) were quantified. Statistical significance in (c, d) determined by ratio-paired T test: *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

    Journal: bioRxiv

    Article Title: Antigen-scaffolds drive preferential expansion of functional genetically engineered CAR and TCR T cells

    doi: 10.1101/2025.11.01.686037

    Figure Lengend Snippet: ( a ) BLI luminescence quantification of luciferase signal day 21 after intravenous inoculation of Luciferase-transduced JEKO-1 cell in immunodeficient NXG mice (n=5 per group) and injection of 0.5M CAR T cells expanded with IL2/7/15 or Ag-scaffolds on day 7. Cell numbers were adjusted for the actual number of CAR- expressing T cells. (b) Quantification of cancer cell growth from luminescence signal (e-/sec) over time following injection of 0.25M or 0.5M CAR T cells 7 days after jeko-1 injection (n=5 mice per group). Mice were terminated when reaching a predefined humane endpoint. (c-e) On day 30, spleens and bone marrow (BM) from the IL2/7/15 and Ag-scaffold-expanded 0.5M CAR T cell groups were analysed by flow cytometry, and CAR T cell percentages ( c ) representative flow plots showing CD3 + CAR T cell population (top) and CD3 + CD4 + & CD3 + CD8 + T cells(bottom) and numbers of CAR T cells ( d ) were quantified. Statistical significance in (c, d) determined by ratio-paired T test: *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

    Article Snippet: For the efficacy study, 7–10-week-old female immunodeficient NXG mice (NOD-Prkdcscid-IL2rgTm1/Rj; Janvier Labs) were intravenously injected with 1 × 106 luciferase-expressing Jeko-1 cells.

    Techniques: Luciferase, Injection, Expressing, Flow Cytometry